AVP and hyperinsulinemic hypoglycemia, familial, 4: Additionally, OXTRs are expressed in bothosteoblasts and osteoclasts (17), and OXT has anabolic effects on bone, promotesossification, and inhibits bone resorption (17-19).Clinically, low OXT levels have been associated with reduced bone mineraldensity (BMD) in patients with AVP-Deficiency (20).