OXT and neurohypophyseal diabetes insipidus: Given the anatomicallocation of hypothalamic OXT-producing neurons, patients withhypothalamic-pituitary dysfunction who develop AVP-Deficiency (64), often due to suprasellarlesions such as craniopharyngiomas (CP) and germinomas or followinghypothalamicpituitary surgery, are presumably at the highest risk forco-existing OXT-Deficiency (65-70).Other causes include infiltrative or malignant diseases, neurosurgery,radiotherapy, head trauma, and congenital abnormalities.