In a retrospective analysisof 228 patients investigated for hyperandrogenism, 44.3% had hirsutism withelevated androgens and eumenorrhea, 27.6% had polycystic ovary syndrome (definedas hirsutism, elevated androgens, and oligomenorrhea), 22.4% had normalandrogens with acne or alopecia and eumenorrhea, 3.1% had isolated lowsex-hormone binging globulin (SHBG), 1.8% had nonclassical congenital adrenalhyperplasia, and 0.9% had ovarian tumors. This evidence concerns the gene SHBG and acne.