The use of the product FSH(IU/l)×inhibin B (ng/mL) < 92 or FSH (IU/l)×AMH (pmol/l)< 537 show high sensitivity (>93%), specificity (≥92%) andpositive predictive value (>92%) for CHH in male patients aged ≥13 and < 18 years presenting with a testicular volume < 4 mL and noother sign of pubertal onset (Figure4) (48). Here, BRD2 is linked to cartilage-hair hypoplasia.