FBXW7 and colorectal carcinoma: To investigate the impact of FBW7 expression level on SN38 resistance in CRC cells, we established FBW7‐knockdown RKO cells, FBW7‐knockout HCT‐116 and DLD1 cells using CRISPR/Cas9 gene editing, as well as FBW7‐knockdown HCT‐116 cells through RNA interference.