In contrast, FBW7‐mutant cell lines (LOVO, SW1463, SW48, and HCT‐8) exhibited significantly higher IC50 values (634.70, 868.70, 1195.6, and 1883.09 nM, respectively; p < 0.0001, Figure 2A), suggesting that FBW7 mutations significantly reduce SN38 sensitivity in CRC cells. This evidence concerns the gene FBXW7 and colorectal carcinoma.