In AD context, previous studies showed that TSCs derivates have the ability to inhibit Aβ self or Cu‐induced aggregation, antioxidant activity, acetylcholinesterase (AChE) activity, and have low toxicity in cell models and a suitable permeability through BBB [72, 73, 74, 75, 76, 77, 78, 79, 80]. Here, ACHE is linked to Alzheimer disease.