Advanced age, male, elevated BMI, prolonged duration of diabetes, comorbid nephropathy, comorbid neuropathy, comorbid retinopathy, elevated systolic blood pressure, elevated FBS, elevated HbA1c, elevated triglycerides, elevated fibrinogen, elevated WBC count, elevated CRP, decreased ankle‐brachial ratio, decreased total protein levels are DFU risk factors. This evidence concerns the gene CRP and neuropathy.