Consequently, LAMP2-deficient mice, a model of X-linked recessive Danon disease in humans, develop features strongly resembling chronic pancreatitis, including tissue disorganisation, macrophagic infiltration and stellate cell activation, and demonstrate substantially decreased intra-pancreatic levels of digestive enzymes, strongly suggestive of pancreatic insufficiency. The gene discussed is LAMP2; the disease is exocrine pancreatic insufficiency.