GPT and hepatocellular carcinoma: And for patients with positive serum HBV DNA, regardless of ALT levels, antiviral therapy is recommended as long as one of the following conditions is met: (a) family history of hepatitis B cirrhosis or HCC; (b) older age (over 30 years); (c) the demonstration of significant liver necroinflammation or fibrosis assessed by invasive or non-invasive examination; (d) HBV related extrahepatic manifestations.