REG3G and infection: However, treatment with diallyl disulfide (a garlic-derived compound) mitigated the effect of ethanol treatment.83 Acute ethanol exposure also impaired the clearance of methicillin-resistant Staphylococcus aureus in the lung by reducing epithelial production of Reg3gamma, an antimicrobial peptide critical for bacterial killing.84 Similarly, individuals with AUD exhibited reduced antimicrobial proteins in epithelial lining fluid, which was associated with compromised antipneumococcal activity and increased infection risk.85