CPT1A and neoplasm: Accumulating evidence indicates that their immunosuppressive activity is closely linked to lipid metabolic reprogramming.First, tumor-associated MDSCs frequently shift from glycolysis to fatty acid oxidation (FAO), characterized by high expression of CD36 and broad upregulation of FAO-related genes, including CPT1A and other key regulators, which enhances FAO and promotes the production of suppressive mediators (50, 51).