KRT3 and precursor B-cell acute lymphoblastic leukemia: To construct the landscape of cell type-specific open chromatin features and gene expression profile at the single cell level, we performed sc-RNASeq and scATAC-seq analysis on PBMCs samples from six high risk pediatric B-ALL patients with and three healthy controls (CK1, CK2, CK3) to explore their cellular composition (Supplementary Figure S1).