Its latent infection continuously activates the immune system, leading to elevated levels of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in serum, thereby inducing a state of “inflammaging” (Franceschi et al., 2007; Wang et al., 2010). Here, IL6 is linked to disease arising from reactivation of latent virus.