In recent years, researchers have successively identified several new pathogenic genes associated with HAE, including the genes encoding coagulation factor XII (F12) (5–7), angiopoietin-1 (ANGPT1) (8), plasminogen (PLG) (9, 10), kininogen-1 heavy chain (KNG1) (11), myoferlin (MYOF) (12), heparan sulfate glucosamine 3-O-sulfotransferase 6 (HS3ST6) (13), carboxypeptidase N (CPN) (14), and DAB2 interacting protein (DAB2IP) (15). This evidence concerns the gene HS3ST6 and hereditary angioedema.