FUS and amyotrophic lateral sclerosis: Cell-derived and yeast RNAs promoteLLPS of FUS below a specific RNA concentration, whereas excessiveRNA concentrations lead to the dissolution of the droplets., FUS is homogeneously distributed in the nucleus of HeLa cells; however,degradation of nuclear RNA causes the formation of FUS droplets, suggestingthat the nuclear RNA acts to inhibit LLPS of FUS, which is considered to be one of the key mechanisms thatprevents its aggregation and the subsequent onset of ALS.