BDNF and major depressive disorder: Glucocorticoids, including corticosterone, interact with BDNF in the brain to modify synapses and these interactions are associated with stress and depression resilience (Tapia-Arancibia et al., 2004;Kunugi et al., 2012;Jeanneteau and Chao, 2013;Numakawa et al., 2013;Daskalakis et al., 2015).