IL-17 A-induced inflammatory mediators, including IL-6, IL-1β, Ptgs2, Csf2, and Cxcl1, can cause myocardial inflammation and depression [[10], [11], [12],14], and have been associated with endotoxin-induced cardiac dysfunction and shock [14,[51], [52], [53], [54]]. Here, PTGS2 is linked to major depressive disorder.