IL1B and gout: Another study showed that celastrol can block NLRP3 K63 deubiquitination, which may involve the interaction of celastrol with the BRCA1/BRCA2 complex subunit 3 (BRCC3), thereby preventing the formation of the NLRP3, ASC, and pro-caspase-1 complex, blocking the production of mature IL-1β, and alleviating MSU-induced gouty arthritis (Yan et al., 2021).