Yanqiu Xu et al. constructed a co-regulatory ceRNA network of circRNAs and lncRNAs in gouty arthritis, finding that upstream genes in the co-regulatory network (circRNA novel_circ_0030384 and lncRNAs AAMP, TRIM16, PKN1, XLOC_184579, and XLOC_189826) upregulate miR550a-5p and miR550a-3-5p and downregulate PSME1 and FERMT3 expression, and the downregulation of PSME1 and FERMT3 exacerbates gouty arthritis in vitro. The gene discussed is PKN1; the disease is gout.