NLRP3 and gout: Studies have shown that the deubiquitinating enzyme USP16 induces gouty arthritis through Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation, with the mechanism being that USP16 mediates Drp1 deubiquitination and stabilization through direct interaction with Drp1 (Wang and Qiu, 2023).