Inhibition of BRD4 in CRC cells triggers endoplasmic reticulum stress and enhances the transcriptional induction of death receptor 5 (DR5), a key component of the extrinsic apoptotic pathway, which promotes the chemosensitization and apoptotic effects of BET inhibitors (Tan et al., 2019). Here, TNFRSF10B is linked to colorectal carcinoma.