Specifically, we documented that, in the inflamed tissue of IBD patients, IL-34 and BRD4 co-localize in both lamina propria mononuclear cells (LPMCs) and epithelial cells, and knockdown of BRD4 in IBD LPMCs with a specific antisense oligonucleotide reduced IL-34 production. The gene discussed is IL34; the disease is inflammatory bowel disease.