For example, the stabilized HIF-2α by roxadustat also promoted the expression of cellular iron exporter ferroportin (Fpn) (Figure 6G), and mobilized iron export out of renal cells, which may also contribute to the reduction of iron-induced renal fibrosis (Patino et al., 2023; Wu et al., 2024). Here, SLC40A1 is linked to renal fibrosis.