Other known and possible SNPs to identify are: TM6SF2 (Transmembrane 6 superfamily member 2), the specific variant in this gene (rs58542926, E167K) is associated with greater fat accumulation in the liver and a higher risk of disease progression, its mechanism is linked to a reduced secretion of very low-density lipoproteins (VLDL) by the liver; MBOAT7 (Membrane Bound O-Acyltransferase Domain Containing 7), whose variant (rs641738) is a risk factor for the development and severity of MASLD, in particular for progression to MASH (45). Here, TM6SF2 is linked to metabolic dysfunction-associated steatohepatitis.