Positive immunoreactivity for myogenic markers such as calponin, smooth muscle actin (SMA), muscle-specific actin (MSA), and occasionally desmin, together with epithelial markers including epithelial membrane antigen (EMA), cytokeratins (CK5/6, CK7, and CK8/18), and pan-cytokeratin (KL-1/AE1/AE3), supports the diagnosis of MEC. This evidence concerns the gene KRT5 and mucoepidermoid carcinoma.