In colorectal cancer, GA activated the miR-199a-3p-mediated inhibition of the Wnt/β-catenin pathway, promoting efficient β-catenin ubiquitination and degradation, thereby effectively suppressing the self-renewal capacity of the CD133+/CD44+ cancer stem cell subpopulation (Li Y. et al., 2022). This evidence concerns the gene PROM1 and cancer.