HMGB1 and neoplasm: Finally, multidimensional immunomodulation: converting “cold tumors” into “hot tumors.” GA-induced pyroptosis and immunogenic cell death (ICD) release abundant tumor-associated antigens and danger signals (e.g., HMGB1, ATP) (Xu et al., 2022; Zhang D. et al., 2021), which efficiently promote DC maturation (Li L. et al., 2022; Liu et al., 2021) and generate an “in situ vaccination” effect that initiates the immune cycle.