COL4A1 and COL4A1/A2-related disorder: In this study, we show that our multimodal MRI approach can detect radiological features of cSVD in Col4a1 mutant mice that are similar to those observed in individuals with Gould syndrome, and extend our previous findings of allelic heterogeneity contributing to the variability of cerebrovascular manifestations in Col4a1 mutant mice (Jeanne et al., 2015).