(1−2e−TR/T1).2e−TE/T2, the absence of white matter hyperintensity in this study could be attributed to the current FLAIR sequence lacking enough SNR to afford adequate tissue contrast at 14.1 T. Alternatively, leukoencephalopathy, like porencephaly or schizencephaly, may have a low prevalence in the Col4a1 mutant mice studied here, and further large-scale studies with a wider age range and a more white matter-specific pathological validation (like Luxol Fast Blue staining) are needed to investigate this possibility. The gene discussed is COL4A1; the disease is schizencephaly.