ALK and non-small cell lung carcinoma: Moreover, EVs also shuttle oncogenic proteins and RNAs; for instance, EVs from NSCLC patients were found to carry EGFR mutations and oncogenic ALK–EML4 fusions, potentially enabling detection of driver mutations from blood (Rabinowits et al., 2009; Rolfo et al., 2017; Yanaihara et al., 2006).