These biomarkers bestow significant prognostic and prescient importance, exemplified by the strong prescient capacity of MGMT methylation status with respect to temozolomide adequacy (Stupp et al., 2005), whereas IDH transformations categorize a unmistakable subset of gliomas related with more favorable clinical results and one of a kind epigenomic characteristics (Wanis et al., 2024). The gene discussed is IDH2; the disease is glioma.