In LPS-induced sepsis rat model, PF pretreatment inhibited PI3K/Akt/ERK-mediated HIF-1α and TLR4/MyD88/NF-κB signaling, thereby reducing inflammation by decreasing the levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in serum and cardiac tissue. This evidence concerns the gene TLR4 and Sepsis.