Several cytokines including TNF-α, TGF-β, and different interleukins (ILs) such as IL-1, IL-4, IL-6, IL-8, and IL-18 are involved in the development of various inflammatory cardiac pathologies, namely, ischemic heart disease, myocardial infarction, heart failure, and cardiomyopathies. The gene discussed is TNF; the disease is coronary artery disorder.