Of these patients, 222 (48.7%) were over 75 years old, 273 (59.9%) were male, 152 (33.3%) had a tumor diameter > 5 cm, 225 (49.3%) had an SMI > 40 kg/m2, 289 (63.4%) had a CEA level > 3.41 ng/mL, 347 (76.1%) had T3 or T4 staging, 82 (18.0%) had N2 staging, 198 (43.4%) had a Ki-67 index >75%, 180 (39.5%) had neural invasion, 111 (24.3%) had vascular invasion, and 22 (4.8%) received preoperative neoadjuvant therapy. The gene discussed is CEACAM5; the disease is neoplasm.