Furthermore, ROCK2 enhances the expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in endothelial cells [23], fostering a proinflammatory microenvironment that promotes leukocyte infiltration and perpetuates kidney injury. The gene discussed is ICAM1; the disease is urogenital neoplasm.