Concurrently, the phosphorylation levels of RelA and STAT3 were significantly suppressed, and mRNA levels of AD-related cytokines (e. g., IL-1β, IL-4, IL-5, IL-6, IL-13, IL-31, and IL-33) and chemokines (e. g., CCL17, CCL22) were notably downregulated.133. This evidence concerns the gene CCL22 and Alzheimer disease.