This mechanism facilitates dual internalization pathways: CD44 receptor-mediated endocytosis induces a proton sponge effect in endo/lysosomes, releasing CRISPR/Cas9-Bcl-2 (pCRISPR) and Bax plasmids (pBax) for apoptosis induction, while cell membrane perforation allows transcellular penetration into neighboring tumor cells. Here, BCL2 is linked to neoplasm.