Chromatin conformation analyses in endothelial cells revealed non-coding ABO variants (rs657152, rs9411377, rs660340, and rs505922) associated with VWF levels, VTE risk, and COVID-19 severity, located in spatial proximity to ADAMTS13. ADAMTS13 is a key regulator of VWF activity, and both ADAMTS13 and VWF play crucial roles in coagulation and thrombosis. Here, ADAMTS13 is linked to COVID-19.