Inhibition of PARP1 has been shown to protect against age‐related endothelial dysfunction in both cerebromicrovascular and cardiovascular systems (Pacher et al. 2004; Radovits et al. 2007; Zhang et al. 2015; Tarantini et al. 2019; Zhan et al. 2023). This evidence concerns the gene PARP1 and endothelial dysfunction.