Haubner et al. suggested CD33 and TIM-3 as an adequate pair for “AND” gating because, although CD33 has a broad expression profile, TIM-3 expression is more restricted, so overlap occurs mainly in AML tumor cells and possibly monocytes, sparing HSPC and vital tissues [28] (Table 1). Here, HAVCR2 is linked to acute myeloid leukemia.