For example, histone deacetylase (HDAC) inhibition upregulates NKG2DL, which is otherwise expressed at low levels, improving the cytotoxicity of NKG2DL-CAR-T cells [86]; epigenetic modulators have been shown to increase CD70 expression on LSC in a clinical trial (NCT03030612) [55], and to effectively enhance the anti-tumor activity of CD70-CAR-T cells in a preclinical study [80]; and all-trans retinoic acid can boost CD38 expression to improve CD38-targeting efficacy [85]. The gene discussed is CD38; the disease is neoplasm.