ARHGEF12 and bladder transitional cell carcinoma: LARG has been implicated in immune regulation and cytoskeletal dynamics; for example, lentiviral shRNA-mediated LARG knockdown impairs megakaryocyte maturation and alters actin cytoskeleton organization via RhoA/ROCK signaling, contributing to diverse pathological processes.In our study, high ARHGEF12 expression correlated with poor prognosis in BLCA patients.