MITF and neoplasm: Although the functional roles of MITF/TFE3 in SPN are not clear at this point, MITF/TFE family transcription factors increased lysosomal breakdown in PDAC cell lines and provided tumor cells with intracellular and extracellular nutrients [60, 61], suggesting that MITF/TFE3 may have similar roles in SPN for survival in low-nutrient environments.