MITF and pancreatic neoplasm: Since these pathways are transcriptionally regulated by the MITF/TFE family via CLEAR (Coordinated Lysosomal Expression and Regulation) elements [48], we hypothesized that this family, specifically MITF, TFE3, and TFEB, may be overexpressed in SPN and represent key regulatory features distinguishing SPN from other pancreatic tumors.