This is consistent with our finding that MITF and TFE3, upstream transcription factors of lysosome-related genes [48], are overexpressed in SPN, but not in four other pancreatic tumor types (PDAC, PanNET, ACC, and PBL) or benign pancreatic tissues (Fig. 3A, B, C). The gene discussed is TFE3; the disease is pancreatic neoplasm.