This is consistent with our finding that MITF and TFE3, upstream transcription factors of lysosome-related genes [48], are overexpressed in SPN, but not in four other pancreatic tumor types (PDAC, PanNET, ACC, and PBL) or benign pancreatic tissues (Fig. 3A, B, C). Here, TFE3 is linked to adrenal cortex carcinoma.