Since these pathways are transcriptionally regulated by the MITF/TFE family via CLEAR (Coordinated Lysosomal Expression and Regulation) elements [48], we hypothesized that this family, specifically MITF, TFE3, and TFEB, may be overexpressed in SPN and represent key regulatory features distinguishing SPN from other pancreatic tumors. Here, TFE3 is linked to pancreatic neoplasm.