Analysis of obesity-related indicators stratified by sex showed that Bio-T was significantly and negatively associated with BMI in males [−0.068 (−0.134, −0.002)], SHBG was significantly and negatively associated with BMI-adjusted waist circumference [−0.065 (−0.104, −0.025)] and BMI-adjusted WHR [−0.066 (−0.106, −0.027)]. This evidence concerns the gene SHBG and obesity due to melanocortin 4 receptor deficiency.