While NPM1 and KMT2A-r leukemias are the commonly encountered genetic aberrations that are dependent on menin pathway, there are several other relatively smaller subgroups, particularly in AML (like AML with NUP98 rearrangement, UBTF1 mutation, others), which are also MEIS/HOX dependent and may be amenable to menin inhibition [4, 6, 13]. The gene discussed is MEN1; the disease is acute myeloid leukemia.