Guided by the selective GBC decreases in neuroinflammation-susceptible regions (pallidum, frontal pole, orbitofrontal cortex) and the positive coupling between our GBC-transcriptomic signature and reductions in IL-6, we hypothesize that acupuncture may down-modulate neuroinflammation—particularly astrocyte-enriched processes—which subsequently may normalize large-scale functional connectivity and alleviates insomnia. Here, IL6 is linked to insomnia.