Given that CD45+ cells were found in close proximity to ECs in MCTS (Figs. 6B, 7K-L), and that we also identified CD45+CD163+ cells close to CD31+ vessels in NSCLC tumor biopsies by multiplex spatial proteomic detection (Fig. 7M), we used CellChat to predict ligand-receptor interactions between MCTS macrophages and EC subsets, in order to identify therapeutically relevant targets. The gene discussed is PTPRC; the disease is non-small cell lung carcinoma.