CD274 and non-small cell lung carcinoma: The different 2D cocultures with the A549 NSCLC cell line led to high heterogeneity with the emergence of new phenotypes absent from the M1-/M2-controls: M1-like macrophages expressing high level of the immunosuppressive molecule PD-L1, a cluster with intermediate levels of M2-like markers, and a cluster with a mixed phenotype.