The proportion of each T-cell subset infiltrating into the 50 μm radii of a tumour cell was not significant between the two HPV-negative and HPV-positive cohorts at 85.3 vs 78.9% (p = 0.250) for total CD8+ T-cells, 81.9 vs 80.6% (p = 0.250) for total CD4+ T-cells and 82.8 vs 74.3% (p = 0.511) for Treg respectively (Fig. 5b). Here, CD4 is linked to neoplasm.