CD4 and neoplasm: Distances of total CD8+ T-cells (27.1 vs 33.6 μm; p = 0.098), total CD4+ T-cells (31.2 vs 35.5 μm; p = 0.225) and Tregs (30.1 vs 40.6 μm; p = 0.383) to a tumour cell were not statistically different between HPV-negative and HPV-positive OAC (Fig. 5a).