Notably, both SARS-CoV-2-specific and bystander T cells carried increased CD25 expression at 6 M follow-up, whereas at 12 M follow-up, elevated CD25 expression was observed only in SARS-CoV-2-specific CD8+ T cells in LC patients, which suggests either persistent lymphocyte dyshomeostasis and dysregulated cytokine signals or the involvement of TCR-mediated signals in LC. This evidence concerns the gene IL2RA and laryngotracheoesophageal cleft.