In the genes upregulated by CBLL1 depletion the following pathways were enriched: Steroid biosynthesis (hsa00100), Complement and coagulation cascades (hsa04610), TNF signalling pathway (hsa04668), Cell adhesion molecules (CAMs) (hsa04514), NOD-like receptor signalling pathway (hsa04621), Lysosome (hsa04142), Transcriptional misregulation in cancer (hsa05202), Cytokine-cytokine receptor interaction (hsa04060), Human papillomavirus infection (hsa05165), and PI3K-Akt signalling pathway (hsa04151) (Fig. 4K). Here, PIK3CA is linked to cancer.