In the genes upregulated by CBLL1 depletion, the Steroid biosynthesis, Complement and coagulation cascades, TNF signalling pathway, Cell adhesion molecules (CAMs), NOD-like receptor signalling pathway, Lysosome, Transcriptional misregulation in cancer, Cytokine-cytokine receptor interaction, Human papillomavirus infection and PI3K-Akt signalling pathways were enriched. The gene discussed is TNF; the disease is cancer.