In multivariate logistic regression analyses, adjusting for cytokeratin 5 (CK5), P-cadherin and epidermal growth factor receptor (EGFR) (by mRNA data), the BCNS score independently predicted the basal-like phenotype (P ≤ 0.003 for BCNS in all cohorts, Supplementary Table S6). The gene discussed is CDH3; the disease is nevoid basal cell carcinoma syndrome.