The observed correlation between BCNS and both the histopathological HER2 status and the TCGA-HER2-index in Luminal A, Luminal B, and HER2-enriched tumors – but not in Basal-like tumors – supports the notion that HER2 signaling could act as a driver of necrosis-associated biology in specific molecular subgroups. Here, ERBB2 is linked to nevoid basal cell carcinoma syndrome.