However, four of the 24 common microglial DEGs were regulated in opposite directions by obesity in males and females (Unc13a, Atp1a3, and Arhgap33 upregulated in females and downregulated in males; Rbm47 upregulated in males and downregulated in females). This evidence concerns the gene ATP1A3 and obesity due to melanocortin 4 receptor deficiency.