MUC1 and adrenal cortex carcinoma: Therefore, we used recently developed two-dimensional (2D) and three-dimensional (3D) models of primary (NCI-H295R), regionally metastatic (TVBF-7) and distant metastatic (MUC-1) ACC and comprehensively compared candidates related to Wnt signaling, cytoskeleton (such as actin, intermediate filaments and related components of the nuclear lamina), EMT and stemness.