KC7F2 treatment produced ~5.4 times more oeHFs than control conditions (14 HFs events out of 3 × 106 OE cells in a total of 6 grafts), while SOX9 inactivation led to ~9.2 times more oeHF than control conditions (55 HFs events out of 7 × 106 OE cells in a total of 14 grafts; Supplementary Fig. 7J). The gene discussed is SOX9; the disease is Hand-foot syndrome.