For instance, the motif YLLKALFKAL, found in the PDE3A-SLFN12 complex (PDB: 7eg0), was associated with apoptosis induction67 while WIVIIAKYLAQWY, identified in the NEDD8-activating enzyme complex (PDB: 3gzn), was involved in cancer cell growth inhibition68. This evidence concerns the gene NEDD8 and cancer.