We found that overexpression of SLC2A1 reduced the DDP sensitivity of RP11-544M22.13 knockdown-enhanced NSCLC cells (Fig. 4A) and the overexpression of SLC2A1 rescued the decrease of proliferation, invasion and migration ability of NSCLC cells induced by RP11-544M22.13 knockdown (Fig. 4C, E, G). The gene discussed is SLC2A1; the disease is non-small cell lung carcinoma.