As expected7,12,13, CG methylation over CG hypo DMRs was dramatically decreased in the wild-type VN nuclei, whereas CHH methylation over CHH hyper DMRs decreased in MN, remained low in GN and SN, and greatly increased in the VN (Fig. 3d, e, Supplementary Fig. 7c)13. This evidence concerns the gene RMRP and ganglioneuroma.